Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells

4 Aug 2011

Abstract excerpt

In this study, we systematically compare two vector design strategies for recombinant monoclonal antibody (Mab) synthesis by Chinese hamster ovary (CHO) cells; a dual open reading frame (ORF) expression vector utilizing separate cytomegalovirus (CMV) promoters to drive heavy chain (HC) and light chain (LC) expression independently, and a single ORF vector design employing a single CMV promoter to drive HC and LC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral Infections and Immunology Research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21882365
DOI: 10.1002/btpr.692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cellsPMID 21882365Read ↗

Cell line‐specific control of recombinant monoclonal antibody production by CHO cellsSemantic proximity Read ↗

Evaluation of different vector design strategies for the expression of recombinant monoclonal antibody in CHO cellsSemantic proximity Read ↗

On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO CellsSemantic proximity Read ↗

Gene copy number, gene configuration and LC / HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell linesSemantic proximity Read ↗

Enhancing recombinant antibody yield in Chinese hamster ovary cellsSemantic proximity Read ↗

A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cellsSemantic proximity Read ↗

A systemic approach to identifying sequence frameworks that decrease mAb production in a transient Chinese hamster ovary cell expression system.Semantic proximity Read ↗

Regulation of Recombinant Monoclonal Antibody Production in Chinese Hamster Ovary Cells: A Comparative Study of Gene Copy Number, mRNA Level, and Protein ExpressionSemantic proximity Read ↗

Recombinant Antibody Production Using a Dual-Promoter Single Plasmid SystemSemantic proximity Read ↗

Increase recombinant antibody yields through optimizing vector design and production process in CHO cellsSemantic proximity Read ↗

Optimizing Bispecific Antibody Expression via Multi-Omics Analysis and Vector RedesignSemantic proximity Read ↗

Identifying bottlenecks in transient and stable production of recombinant monoclonal‐antibody sequence variants in chinese hamster ovary cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.