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Age-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates

6 Feb 2024

Abstract excerpt

The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering age, sex and proximal-distal variations, we used a multi-omics approach in non-human primates (Macaca fascicularis) to shed light on the heterogeneity of intestinal aging and identify potential regulators of gut...

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PMID: 38321225
DOI: 10.1038/s43587-024-00572-9

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