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Colonic Aging and Colorectal Cancer: An Unignorable Interplay and Its Translational Implications

3 Jul 2025

Abstract excerpt

Colorectal cancer (CRC) incidence increases markedly with age, yet chronological age is an inadequate proxy for the complex biological processes involved. Colon aging, the intrinsic biological aging of the colonic tissue, is emerging as a crucial, active driver of CRC development. This review comprehensively analyzes the interplay between colon aging and CRC pathogenesis by examining fundamental hallmarks of...

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PMID: 40723364
DOI: 10.3390/biology14070805

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