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Rational thresholding of circulating tumor DNA concentration for improved surveillance of metastatic breast cancer

1 Feb 2024

Abstract excerpt

BACKGROUND: The use of circulating tumor DNA (ctDNA) concentration for metastatic cancer surveillance is promising, but uncertainty remains about cut-offs with clinical validity. MATERIALS AND METHODS: This observational study recruited 136 subjects with advanced metastatic breast cancer (irrespective of ERBB2/hormone receptor status) for sequencing of their primary tumor in search for PIK3CA hotspot variants...

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PMID: 38320429
DOI: 10.1016/j.esmoop.2024.102235

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