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Cuproptosis-related genes predict prognosis and trastuzumab therapeutic response in HER2-positive breast cancer

5 Feb 2024

Abstract excerpt

Breast cancer is the most common diagnosed cancer, the HER2-positive subtype account for 15% of all breast cancer. HER2-targeted therapy is the mainstay treatment for HER2-positive breast cancer. Cuproptosis is a novel form of programmed cell death, and is caused by mitochondrial lipoylation and destabilization of iron-sulfur proteins triggered by copper, which was considered as a key player in various biological...

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PMID: 38316885
DOI: 10.1038/s41598-024-52638-8

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