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Article

A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.

Sleep - 10 May 2024

Leu Chia-Luen, Lam Daniel D, Salminen Aaro V, Wefers Benedikt, Becker Lore, Garrett Lillian, Rozman Jan, Wurst Wolfgang, Hrabě de Angelis Martin, Hölter Sabine M, Winkelmann Juliane, Williams Rhîannan H

Abstract excerpt

Restless legs syndrome (RLS) is a neurological disorder characterized by uncomfortable or unpleasant sensations in the legs during rest periods. To relieve these sensations, patients move their legs, causing sleep disruption. While the pathogenesis of RLS has yet to be resolved, there is a strong genetic association with the MEIS1 gene. A missense variant in MEIS1 is enriched sevenfold in people with RLS compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38314840
DOI: 10.1093/sleep/zsae015
PMCID: PMC11502956

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