Article
Meis1: effects on motor phenotypes and the sensorimotor system in mice.
Disease models & mechanisms - 1 Aug 2017
Salminen Aaro V, Garrett Lillian, Schormair Barbara, Rozman Jan, Giesert Florian, Niedermeier Kristina M, Becker Lore, Rathkolb Birgit, Rácz Ildikó, Klingenspor Martin, Klopstock Thomas, Wolf Eckhard, Zimmer Andreas, Gailus-Durner Valérie, Torres Miguel, Fuchs Helmut, Hrabě de Angelis Martin, Wurst Wolfgang, Hölter Sabine M, Winkelmann Juliane
Abstract excerpt
MEIS1 encodes a developmental transcription factor and has been linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder leading to severe sleep reduction and has a substantial impact on the quality of life of patients. In genome-wide association studies, MEIS1 has consistently been the gene with the highest effect size and functional studies suggest a disease-relevant...
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