Article
Somatic Mutation of PRKAR1A in Four Cases of Sporadic Cardiac Myxoma.
Archives of Iranian medicine - 1 Jun 2023
Sun Yunpeng, Li Zhiping, Sun Jingnan, Ma Dashi, Shan Xue, Chen Xia
Abstract excerpt
BACKGROUND: Inactivating mutations of the protein kinase A regulatory subunit 1 alpha (PRKAR1A) gene have been reported in familial cardiac myxoma. However, the role of PRKAR1A mutation in sporadic cardiac myxoma remains unknown. METHODS: Targeted next-generation sequencing (NGS) was performed to identify mutations with the PRKAR1A gene in seven cases of sporadic cardiac myxomas. Sanger sequencing of DNA from...
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