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Article

Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer.

Journal of translational medicine - 3 Feb 2024

Yang Huan, Xiao Xing, Zeng Leli, Zeng Haiteng, Zheng Yueyuan, Wang Jingshu, Li Guanghua, Dai Weigang, He Yulong, Wang Suihai, Peng Jianjun, Chen Wei

Abstract excerpt

BACKGROUND: The current precision medicine relies on biomarkers, which are mainly obtained through next-generation sequencing (NGS). However, this model failed to find effective drugs for most cancer patients. This study tried to combine liquid biopsy with functional drug tests using organoid models to find potential drugs for cancer patients. METHODS: Colorectal cancer (CRC) patients were prospectively enrolled...

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Source

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Identifiers

PMID: 38310289
DOI: 10.1186/s12967-023-04675-6
PMCID: PMC10837874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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