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A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation

3 Feb 2024

Abstract excerpt

BACKGROUND: Male infertility is a global health issue. The more causative genes related to human male infertility should be further explored. The essential role of Zcwpw1 in male mouse fertility has been established and the role of ZCWPW1 in human reproduction needs further investigation to verify. METHODS: An infertile man with oligoasthenoteratozoospermia phenotype and his parents were recruited from West China...

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PMID: 38310235
DOI: 10.1186/s12978-024-01746-9

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