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Targeting Efficient Features of Urate Oxidase to Increase Its Solubility.

Applied biochemistry and biotechnology - 1 Sept 2024

Rahbar Mohammad Reza, Nezafat Navid, Morowvat Mohammad Hossein, Savardashtaki Amir, Ghoshoon Mohammad Bagher, Mehrabani-Zeinabad Kamran, Ghasemi Younes

Abstract excerpt

With the demand for mass production of protein drugs, solubility has become a serious issue. Extrinsic and intrinsic factors both affect this property. A homotetrameric cofactor-free urate oxidase (UOX) is not sufficiently soluble. To engineer UOX for optimum solubility, it is important to identify the most effective factor that influences solubility. The most effective feature to target for protein engineering...

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PMID: 38308671
DOI: 10.1007/s12010-023-04819-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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