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Article

Interval estimate of causal effect in summary data based Mendelian randomization in the presence of winner's curse.

Genetic epidemiology - 1 Mar 2024

Wang Kai

Abstract excerpt

This research focuses on the interval estimation of the causal effect of an exposure on an outcome using the summary data-based Mendelian randomization (SMR) method while accounting for the winner's curse caused by the selection of single nucleotide polymorphism instruments. This issue is understudied and is important as the point estimate is biased. Since Fieller's theorem and its variations are not suitable for...

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PMID: 38282283
DOI: 10.1002/gepi.22545

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