Article
A novel biallelic 19-bp deletion in the IL10RB gene caused infant-onset inflammatory bowel disease in a consanguineous family: a molecular docking simulation study and literature review.
Molecular biology reports - 28 Jan 2024
Motallebi Farzaneh, Al Sudani Zainab M, Vaghefi Fatemeh, Khosravi Teymoor, Rahimzadeh Arian, Kowsari Ali, Oladnabi Morteza
Abstract excerpt
BACKGROUND: Infantile-onset inflammatory bowel disease (IOIBD) is a gastrointestinal inflammatory condition often associated with monogenic disorders and is frequently caused by Interleukin-10 deficiencies. This study aimed to identify the mutation responsible for IBD in an 8-year-old patient from an Iranian family with consanguineous parents. METHODS: Whole-exome sequencing (WES) was employed to identify...
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