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Variant ALK ‐fusion positive anaplastic large cell lymphoma ( ALCL ): A population‐based paediatric study of the NHL‐BFM study group

26 Jan 2024

Abstract excerpt

Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive of a variant ALK-partner; 41 were analysed by genomic capture high-throughput sequencing or specific RT-PCRs. NPM1::ALK was detected in 13 cases. Among the 28...

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PMID: 38279625
DOI: 10.1111/bjh.19308

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