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Article

Respiratory Syncytial Virus Genotypes, Host Immune Profiles, and Disease Severity in Young Children Hospitalized With Bronchiolitis.

The Journal of infectious diseases - 27 Dec 2017

Rodriguez-Fernandez Rosa, Tapia Lorena I, Yang Chin-Fen, Torres Juan Pablo, Chavez-Bueno Susana, Garcia Carla, Jaramillo Lisa M, Moore-Clingenpeel Melissa, Jafri Hasan S, Peeples Mark E, Piedra Pedro A, Ramilo Octavio, Mejias Asuncion

Abstract excerpt

Background: Data on how respiratory syncytial virus (RSV) genotypes influence disease severity and host immune responses is limited. Here, we characterized the genetic variability of RSV during 5 seasons, and evaluated the role of RSV subtypes, genotypes, and viral loads in disease severity and host transcriptional profiles. Methods: A prospective, observational study was carried out, including a convenience...

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PMID: 29045741
DOI: 10.1093/infdis/jix543
PMCID: PMC5853407

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