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The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

23 Oct 2023

Abstract excerpt

Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from immunotherapy, and the underlying mechanisms remain understudied. Here, we identify that fibrinogen-like protein 1 (FGL1), secreted from cancer cells and hepatocytes, facilitates the progression of CRC in an intraportal injection model by reducing the infiltration of T cells. Mechanistically, tumor-associated macrophages...

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PMID: 37872170
DOI: 10.1038/s41467-023-42332-0

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