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Oncolytic H-1 Parvovirus Hijacks Galectin-1 to Enter Cancer Cells

11 May 2022

Abstract excerpt

Clinical studies in glioblastoma and pancreatic carcinoma patients strongly support the further development of H-1 protoparvovirus (H-1PV)-based anticancer therapies. The identification of cellular factors involved in the H-1PV life cycle may provide the knowledge to improve H-1PV anticancer potential. Recently, we showed that sialylated laminins mediate H-1PV attachment at the cell membrane. In this study, we...

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PMID: 35632759
DOI: 10.3390/v14051018

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