Article
Generation of SARS-CoV-2 spike receptor binding domain mutants and functional screening for immune evaders using a novel lentivirus-based system.
Journal of medical virology - 1 Jan 2024
Jia Junli, Garbarino Emanuela, Wang Yuhang, Li Jiaming, Song Minmin, Zhang Xin, Wang Xinjie, Li Lingyun, Chi Jing, Cui Lunbiao, Tang Huamin
Abstract excerpt
The emergence of rapid and continuous mutations of severe acute respiratory syndrome 2 (SARS-CoV-2) spike glycoprotein that increased with the Omicron variant points out the necessity to anticipate such mutations for conceiving specific and adaptable therapies to avoid another pandemic. The crucial target for the antibody treatment and vaccine design is the receptor binding domain (RBD) of the SARS-CoV-2 spike....
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