Antibody-induced vascular inflammation skews infiltrating macrophages to a novel remodeling phenotype in a model of transplant rejection.

doi:10.1111/ajt.15934

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Article

Antibody-induced vascular inflammation skews infiltrating macrophages to a novel remodeling phenotype in a model of transplant rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Oct 2020

Wei Xuedong, Valenzuela Nicole M, Rossetti Maura, Sosa Rebecca A, Nevarez-Mejia Jessica, Fishbein Gregory A, Mulder Arend, Dhar Jayeeta, Keslar Karen S, Baldwin William M, Fairchild Robert L, Hou Jianquan, Reed Elaine F

Abstract excerpt

HLA donor-specific antibodies (DSAs) binding to vascular endothelial cells of the allograft trigger inflammation, vessel injury, and antibody-mediated rejection (AMR). Accumulation of intragraft-recipient macrophages is a histological characteristic of AMR, which portends worse outcome. HLA class I (HLA I) DSAs enhance monocyte recruitment by activating endothelial cells and engaging FcγRs, but the DSA-activated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32320528
DOI: 10.1111/ajt.15934
PMCID: PMC7529968

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