Article
NF9 peptide specific cytotoxic T lymphocyte clone cross react to Y453F mutation of SARS-CoV-2 virus spike protein.
Immunological medicine - 1 Jun 2024
Murai Aiko, Kubo Terufumi, Ohkuri Takayuki, Yanagawa Junko, Yajima Yuki, Kosaka Akemi, Li Dongliang, Nagato Toshihiro, Murata Kenji, Kanaseki Takayuki, Tsukahara Tomohide, Nagasaki Takeshi, Hirohashi Yoshihiko, Kobayashi Hiroya, Torigoe Toshihiko
Abstract excerpt
The recognition by cytotoxic T cells (CTLs) is essential for the clearance of SARS-CoV-2 virus-infected cells. Several viral proteins have been described to be recognized by CTLs. Among them, the spike (S) protein is one of the immunogenic proteins. The S protein acts as a ligand for its receptors, and several mutants with different affinities for its cognate receptors have been reported, and certain mutations in...
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