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Article

Hedgehog signalling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells.

Cell death & disease - 16 Jan 2024

Lee Chaeyoung, Yi Jawoon, Park Jihwan, Ahn Byungyong, Won Young-Wook, Jeon JiHeung, Lee Byung Ju, Cho Wha Ja, Park Jeong Woo

Abstract excerpt

Although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harbouring KRASG12C, acquired resistance to these therapies eventually occurs in most patients. Re-expression of KRAS is thought to be one of the main causes of acquired resistance. However, the mechanism through which cancer cells re-express KRAS is not fully understood. Here, we report that the Hedgehog signal is induced by...

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Identifiers

PMID: 38225225
DOI: 10.1038/s41419-024-06436-9
PMCID: PMC10789740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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