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Article

Coevolutionary Information Captures Catalytic Functions and Reveals Divergent Roles of Terpene Synthase Interdomain Connections.

Biochemistry - 6 Feb 2024

Nartey Charisse M, Koo Hyun Jo, Laurendon Caroline, Shaik Hana Z, O'maille Paul, Noel Joseph P, Morcos Faruck

Abstract excerpt

Inferring the historical and biophysical causes of diversity within protein families is a complex puzzle. A key to unraveling this problem is characterizing the rugged topography of sequence-function adaptive landscapes. Using biochemical data from a 29 = 512 combinatorial library of tobacco 5-epi-aristolochene synthase (TEAS) mutants engineered to make the native major product of Egyptian henbane...

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PMID: 38206111
DOI: 10.1021/acs.biochem.3c00578
PMCID: PMC10851433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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