Article
Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
Science translational medicine - 10 Jan 2024
Tai Yi-Yin, Yu Qiujun, Tang Ying, Sun Wei, Kelly Neil J, Okawa Satoshi, Zhao Jingsi, Schwantes-An Tae-Hwi, Lacoux Caroline, Torrino Stephanie, Al Aaraj Yassmin, El Khoury Wadih, Negi Vinny, Liu Mingjun, Corey Catherine G, Belmonte Frances, Vargas Sara O, Schwartz Brian, Bhat Bal, Chau B Nelson, Karnes Jason H, Satoh Taijyu, Barndt Robert J, Wu Haodi, Parikh Victoria N, Wang Jianrong, Zhang Yingze, McNamara Dennis, Li Gang, Speyer Gil, Wang Bing, Shiva Sruti, Kaufman Brett, Kim Seungchan, Gomez Delphine, Mari Bernard, Cho Michael H, Boueiz Adel, Pauciulo Michael W, Southgate Laura, Trembath Richard C, Sitbon Olivier, Humbert Marc, Graf Stefan, Morrell Nicholas W, Rhodes Christopher J, Wilkins Martin R, Nouraie Mehdi, Nichols William C, Desai Ankit A, Bertero Thomas, Chan Stephen Y
Abstract excerpt
Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)-dependent vascular dysfunction, HIF-2α promoted expression of neighboring genes, long noncoding RNA (lncRNA) histone lysine N-methyltransferase 2E-antisense 1 (KMT2E-AS1) and histone lysine...
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