Article
High-sensitivity analysis of clonal hematopoiesis reveals increased clonal complexity of potential-driver mutations in severe COVID-19 patients.
PloS one - 1 Jan 2024
Ronchini Chiara, Caprioli Chiara, Tunzi Gianleo, D'Amico Francesco Furio, Colombo Emanuela, Giani Marco, Foti Giuseppe, Conconi Donatella, Lavitrano Marialuisa, Passerini Rita, Pase Luca, Capizzi Silvio, Mastrilli Fabrizio, Alcalay Myriam, Orecchia Roberto, Natoli Gioacchino, Pelicci Pier Giuseppe
Abstract excerpt
Whether Clonal Hematopoiesis (CH) represents a risk factor for severity of the COVID-19 disease remains a controversial issue. We report the first high- sensitivity analysis of CH in COVID-19 patients (threshold of detection at 0.5% vs 1 or 2% in previous studies). We analyzed 24 patients admitted to ICU for COVID-19 (COV-ICU) and 19 controls, including healthy subjects and asymptomatic SARS-CoV2-positive...
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