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Article

Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals.

European journal of clinical pharmacology - 1 Mar 2024

Tveit Kristine, Hermann Monica, Nilsen Roy M, Wallerstedt Susanna M, Rongve Arvid, Molden Espen, Hole Kristine

Abstract excerpt

PURPOSE: The aim of this study was to examine the age of onset for increased dose-adjusted serum concentrations (C/D ratio) of common antidepressant drugs and to explore the potential association with sex and CYP2C19/CYP2D6 genotype. METHODS: Serum concentrations and prescribed daily doses for citalopram, escitalopram, sertraline, venlafaxine and mirtazapine, and CYP genotypes, were obtained from a therapeutic...

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Identifiers

PMID: 38197945
DOI: 10.1007/s00228-023-03611-3
PMCID: PMC10873233

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