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Article

Effect of CYP2D6 genotype on duloxetine serum concentration.

Basic & clinical pharmacology & toxicology - 1 Jan 2024

Hole Kristine, Gangsø Sofie, Jensstuen Åsa Tonette, Ormøy Hanne Holte, Paulsen Maren, Molden Espen, Haslemo Tore

Abstract excerpt

Duloxetine is metabolized by cytochrome P450 (CYP)1A2 and CYP2D6. The aim of this study was to investigate the effect of the CYP2D6 genotype on duloxetine serum concentration adjusting for age and sex. Patients were included retrospectively from a therapeutic drug monitoring service. Multiple linear regression analysis was used to investigate the effect of CYP2D6 genotype, age and sex on the duloxetine...

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PMID: 37864290
DOI: 10.1111/bcpt.13954

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