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Article

Impact of the CYP2D6 genotype on steady-state serum concentrations of aripiprazole and dehydroaripiprazole.

European journal of clinical pharmacology - 1 Dec 2007

Hendset Magnhild, Hermann Monica, Lunde Hilde, Refsum Helge, Molden Espen

Abstract excerpt

OBJECTIVE: Aripiprazole is an atypical antipsychotic drug which is metabolized by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). The aim of the present study was to investigate the impact of the CYP2D6 genotype on serum concentrations of aripiprazole (ARI) and to determine the sum of ARI and the active metabolite dehydroaripiprazole (DARI) in psychiatric patients. METHODS: Data on steady-state serum...

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Adolescent
Aged, 80 and over
Antipsychotic Agents
Cytochrome P-450 CYP2D6
Drug Monitoring

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Pharmacogenetics

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PMID: 17828532
DOI: 10.1007/s00228-007-0373-6

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