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The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

25 Aug 2023

Abstract excerpt

The white-footed deermouse Peromyscus leucopus , a long-lived rodent, is a key reservoir in North America for agents of several zoonoses, including Lyme disease, babesiosis, anaplasmosis, and a viral encephalitis. While persistently infected, this deermouse is without apparent disability or diminished fitness. For a model for inflammation elicited by various pathogens, the endotoxin lipopolysaccharide (LPS) was...

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PMID: 38193896
DOI: 10.7554/elife.90135

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