Article
DNMT3A/TET2/ASXL1 Mutations are an Age-independent Thrombotic Risk Factor in Polycythemia Vera Patients: An Observational Study.
Thrombosis and haemostasis - 1 Jul 2024
Segura-Díaz Adrián, Stuckey Ruth, Florido Yanira, Sobas Marta, Álvarez-Larrán Alberto, Ferrer-Marín Francisca, Pérez-Encinas Manuel, Carreño-Tarragona Gonzalo, Fox María L, Tazón Vega Barbara, Cuevas Beatriz, López Rodríguez Juan F, Sánchez-Farías Nuria, González-Martín Jesús M, Gómez-Casares María T, Bilbao-Sieyro Cristina
Abstract excerpt
BACKGROUND: Polycythemia vera (PV) patients are classified as high or low thrombotic risk based on age and prior history of thrombosis. Despite adherence to treatment recommendations, vascular events remain frequent, leading us to question whether thrombotic risk stratification could be improved. We previously reported an association between thrombotic events and mutations in DTA genes (DNMT3A, TET2, and ASXL1)....
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