A PAX5 P80R pediatric B acute lymphoblastic leukemia with monocytic lineage switch at diagnosis: Deciphering classification ambiguity

Abstract excerpt

To the Editor: Monocytic switch is a well-known phenomenon in acute leukemia with BCR::ABL1 or KMT2a-r, but is a more recent finding in B-acute lymphoblastic leukemia (ALL) with PAX5 P80R or DUX4::IGH genetic alterations. A 14-year-old male was referred for hyperleukocytosis (146k/L) with 92% blasts (Figure 1A) suspicious for acute monocytic leukemia (AMoL). Bone marrow aspirate showed two abnormal populations:...

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