Article
DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch.
Haematologica - 1 Aug 2021
Novakova Michaela, Zaliova Marketa, Fiser Karel, Vakrmanova Barbora, Slamova Lucie, Musilova Alena, Brüggemann Monika, Ritgen Matthias, Fronkova Eva, Kalina Tomas, Stary Jan, Winkowska Lucie, Svec Peter, Kolenova Alexandra, Stuchly Jan, Zuna Jan, Trka Jan, Hrusak Ondrej, Mejstrikova Ester
Abstract excerpt
Recently, we described B-cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype with early switch to the monocytic lineage and loss of the B-cell immunophenotype, including CD19 expression. Thus far, the genetic background has remained unknown. Among 726 children consecutively diagnosed with BCP-ALL, 8% patients experienced switch detectable by flow cytometry (FC). Using exome and RNA sequencing, switch...
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