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Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy

7 Jan 2024

Abstract excerpt

Abstract Background Dilation may be the first right ventricular change and accelerates the progression of threatening ventricular tachyarrhythmias and heart failure for patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), but the treatment for right ventricular dilation remains limited. Methods Single-cell RNA sequencing (scRNA-seq) of blood and biventricular myocardium from 8 study participants...

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PMID: 38185631
DOI: 10.1186/s12916-023-03232-8

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