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Article

The molecular basis of the inhibition of CaV1 calcium-dependent inactivation by the distal carboxy tail.

The Journal of biological chemistry - 1 Jan 2000

Sang Lingjie, Vieira Daiana C O, Yue David T, Ben-Johny Manu, Dick Ivy E

Abstract excerpt

Ca2+/calmodulin-dependent inactivation (CDI) of CaV channels is a critical regulatory process that tunes the kinetics of Ca2+ entry for different cell types and physiologic responses. CDI is mediated by calmodulin (CaM), which is bound to the IQ domain of the CaV carboxy tail. This modulatory process is tailored by alternative splicing such that select splice variants of CaV1.3 and CaV1.4 contain a long distal...

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Identifiers

PMID: 33667546
DOI: 10.1016/j.jbc.2021.100502
PMCID: PMC8054141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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