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Identification of Histone Acetylation Modification Sites in the Striatum of Subchronically Manganese-Exposed Rats

1 Jan 2024

Abstract excerpt

Aim: To explore the specific histone acetylation sites and oxidative stress-related genes that are associated with the pathogenesis of manganese toxicity. Methods: We employed liquid chromatography–tandem mass spectrometry and bioinformatics analysis to identify acetylated proteins in the striatum of subchronic manganese-intoxicated rats. Results: We identified a total of 12 differentially modified histone...

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PMID: 38174439
DOI: 10.2217/epi-2023-0364

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