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Article

Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells

10 Sept 2011

Abstract excerpt

With recent approval of the first dendritic cell (DC) vaccine for patient use, many other DC vaccine approaches are now being tested in clinical trials. Many of these DC vaccines employ tumor cell lysates (TL) generated from cells cultured in atmospheric oxygen (∼20% O₂) that greatly exceeds levels found in tumors in situ. In this study, we tested the hypothesis that TLs generated from tumor cells cultured under...

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PMID: 21908554
DOI: 10.1158/0008-5472.can-11-1166

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