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Biomarker Testing Journey Among Patients with Advanced Solid Tumors and Treatment Patterns by Homologous Recombination Repair Status: A Clinico-Genomic Database Study.

Advances in therapy - 1 Feb 2024

Shao Changxia, Ren Yixin, Zhou Heng, Lee Liam C, Chen Cai, Dettman Elisha J, Cristescu Razvan, Gozman Alexander, Jin Fan, Zhou Wei

Abstract excerpt

INTRODUCTION: Defects in the homologous recombination repair (HRR) pathway can include mutations in BRCA1 and BRCA2 (BRCAm) and other HRR genes (HRRm). These mutations are associated with a homologous recombination deficiency (HRD) phenotype. We evaluated testing journey and treatment patterns by BRCAm, HRRm, and HRD status in a real-world dataset. METHODS: Deidentified data for patients who had undergone...

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PMID: 38169059
DOI: 10.1007/s12325-023-02734-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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