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Article

Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2024

Richardson Debra L, Quintanilha Julia C F, Danziger Natalie, Li Gerald, Sokol Ethan, Schrock Alexa B, Ebot Ericka, Bhardwaj Neeru, Norris Tanesha, Afghahi Anosheh, Frachioni Anthony, Washington Christina, Dockery Lauren, Elvin Julia, Graf Ryon P, Moore Kathleen N

Abstract excerpt

PURPOSE: The purpose of the study was to compare the effectiveness of PARP inhibitor maintenance therapy (mPARPi) in real-world practice by biomarker status [BRCA1/2 alterations (BRCAalt) and a homologous recombination deficiency signature (HRDsig)] in advanced ovarian cancer. EXPERIMENTAL DESIGN: Patients with ovarian cancer receiving first-line platinum-based chemotherapy and either mPARPi or no maintenance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39078736
DOI: 10.1158/1078-0432.CCR-24-1225
PMCID: PMC11474169

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