Characterization of two transcriptomic subtypes of marker-null large cell carcinoma of the lung suggests different origin and potential new therapeutic perspectives.

doi:10.1007/s00428-023-03721-4

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Article

Characterization of two transcriptomic subtypes of marker-null large cell carcinoma of the lung suggests different origin and potential new therapeutic perspectives.

Virchows Archiv : an international journal of pathology - 1 May 2024

Simbolo Michele, Centonze Giovanni, Gkountakos Anastasios, Monti Valentina, Maisonneuve Patrick, Golovco Stela, Sabella Giovanna, Del Gobbo Alessandro, Gobbo Stefano, Ferrero Stefano, Fabbri Alessandra, Pardo Carlotta, Garzone Giovanna, Prinzi Natalie, Pusceddu Sara, Testi Adele, Rolli Luigi, Mangogna Alessandro, Bercich Luisa, Benvenuti Mauro Roberto, Bria Emilio, Pilotto Sara, Berruti Alfredo, Pastorino Ugo, Capella Carlo, Infante Maurizio, Milella Michele, Scarpa Aldo, Milione Massimo

Abstract excerpt

Pulmonary large cell carcinoma (LCC) is an undifferentiated neoplasm lacking morphological, histochemical, and immunohistochemical features of small cell lung cancer, adenocarcinoma (ADC), or squamous cell carcinoma (SCC). The available molecular information on this rare disease is limited. This study aimed to provide an integrated molecular overview of 16 cases evaluating the mutational asset of 409 genes and...

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Identifiers

PMID: 38168015
DOI: 10.1007/s00428-023-03721-4
PMCID: PMC11106141

Genes

AIM2
FOXI1
POU2F3
ATR
CRKL
KEAP1
MYB
MYC
RB1
TP53

Provenance

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