Discrepant low von Willebrand factor activity results on the ACL TOP analyzer are frequent in unselected patients with myeloproliferative neoplasms and show no correlation with high-molecular-weight multimer loss or bleeding phenotype.

Abstract excerpt

BACKGROUND: Bleeding complications are common in patients with myeloproliferative neoplasms (MPNs), with a subset developing acquired von Willebrand disease. Despite this association, a wide spectrum of von Willebrand factor (VWF) abnormalities are described, and the performance of modern assays remains unclear. OBJECTIVES: To comprehensively describe the pattern of VWF laboratory abnormalities in the MPN...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to VWF gene
• Share to Hemorrhage