Article
Clinical phenotype and pathophysiological mechanisms underlying qualitative low VWF.
Blood - 17 Jul 2025
Atiq Ferdows, Blok Robin, van Kwawegen Calvin B, Hulshof Anne-Marije, Doherty Dearbhla, Lavin Michelle, van der Bom Johanna G, O'Connell Niamh M, de Meris Joke, Ryan Kevin, Schols Saskia E M, van Heerde Waander L, Doyle Mairead, Byrne Mary, Heubel-Moenen Floor C J I, van Galen Karin P M, Preston Roger J S, Cnossen Marjon H, Fijnvandraat Karin, Baker Ross I, Meijer Karina, James Paula, Di Paola Jorge, Eikenboom Jeroen, Leebeek Frank W G, O'Donnell James S
Abstract excerpt
ABSTRACT: Previous reports have highlighted that some patients with low von Willebrand factor (VWF) with significant bleeding were diagnosed based on an isolated but persistent reduction in plasma VWF activity levels in the 30 to 50 IU/dL range. These patients had plasma VWF antigen (VWF:Ag) levels >50 IU/dL and thus had qualitative low VWF (low VWF-QL) rather than quantitative low VWF. Although the clinical...
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