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Quantitative Integration of Mode of Action Information in Dose–Response Modeling and POD Estimation for Nonmutagenic Carcinogens: A Case Study of TCDD

1 Dec 2023

Abstract excerpt

BACKGROUND: Traditional dose-response assessment applies different low-dose extrapolation methods for cancer and noncancer effects and assumes that all carcinogens are mutagenic unless strong evidence suggests otherwise. Additionally, primarily focusing on one critical effect, dose-response modeling utilizes limited mode of action (MOA) data to inform low-dose risk. OBJECTIVE: We aimed to build a dose-response...

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PMID: 38157272
DOI: 10.1289/ehp12677

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