Article
The measurement of KRAS G12 mutants using multiplexed selected reaction monitoring and ion mobility mass spectrometry.
Rapid communications in mass spectrometry : RCM - 1 Sept 2020
Norman Rachel L, Singh Rajinder, Langridge James I, Ng Leong L, Jones Donald J L
Abstract excerpt
RATIONALE: There is a considerable clinical demand to determine key mutations in genes involved with cancer which necessitates the deployment of highly specific and robust analytical methods. Multiplex liquid chromatography with selected reaction monitoring (LC/SRM) assays offer the ability to achieve quantitation down to levels expected to be present in clinical samples. Ion mobility mass spectrometry (IMS/MS)...
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