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Article

Differential ion mobility mass spectrometry in immunopeptidomics identifies neoantigens carrying colorectal cancer driver mutations.

Communications biology - 18 Aug 2022

Minegishi Yuriko, Kiyotani Kazuma, Nemoto Kensaku, Inoue Yoshikage, Haga Yoshimi, Fujii Risa, Saichi Naomi, Nagayama Satoshi, Ueda Koji

Abstract excerpt

Understanding the properties of human leukocyte antigen (HLA) peptides (immunopeptides) is essential for precision cancer medicine, while the direct identification of immunopeptides from small biopsies of clinical tissues by mass spectrometry (MS) is still confronted with technical challenges. Here, to overcome these hindrances, high-field asymmetric waveform ion mobility spectrometry (FAIMS) is introduced to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35982173
DOI: 10.1038/s42003-022-03807-w
PMCID: PMC9388627

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