Article
Dissociation between AKAP3 and PKARII Promotes AKAP3 Degradation in Sperm Capacitation
23 Jul 2013
Abstract excerpt
Ejaculated spermatozoa must undergo a series of biochemical modifications called capacitation, prior to fertilization. Protein-kinase A (PKA) mediates sperm capacitation, although its regulation is not fully understood. Sperm contain several A-kinase anchoring proteins (AKAPs), which are scaffold proteins that anchor PKA. In this study, we show that AKAP3 is degraded in bovine sperm incubated under capacitation...
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