Article
Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding.
Haematologica - 1 Aug 2020
Veninga Alicia, De Simone Ilaria, Heemskerk Johan W M, Cate Hugo Ten, van der Meijden Paola E J
Abstract excerpt
Platelets are key elements in thrombosis, particularly in atherosclerosis-associated arterial thrombosis (atherothrombosis), and hemostasis. Megakaryocytes in the bone marrow, differentiated from hematopoietic stem cells are generally considered as a uniform source of platelets. However, recent insights into the causes of malignancies, including essential thrombocytosis, indicate that not only inherited but also...
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