Article
Clinical insights into the origins of thrombosis in myeloproliferative neoplasms.
Blood - 4 Mar 2021
Moliterno Alison R, Ginzburg Yelena Z, Hoffman Ronald
Abstract excerpt
Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are hematopoietic stem cell disorders that are defined by activating mutations in signal transduction pathways and are characterized clinically by the overproduction of platelets, red blood cells, and neutrophils, significant burden of disease-specific symptoms, and high...
Topics
- Animals
- Clonal Hematopoiesis
- Humans
- Inflammation
- Janus Kinase 2
- Mutation
- Myeloproliferative Disorders
- Thrombosis