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Article

Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling

22 Dec 2023

Abstract excerpt

Dysregulation of IL-17A is closely associated with airway inflammation and remodeling in severe asthma. However, the molecular mechanisms by which IL-17A is regulated remain unclear. Here we identify epithelial sirtuin 6 (SIRT6) as an epigenetic regulator that governs IL-17A pathogenicity in severe asthma. Mice with airway epithelial cell-specific deletion of Sirt6 are protected against allergen-induced airway...

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PMID: 38135684
DOI: 10.1038/s41467-023-44179-x

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