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Article

Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes

20 Dec 2023

Abstract excerpt

A major hypothesis for the etiology of type 1 diabetes (T1D) postulates initiation by viral infection, leading to double-stranded RNA (dsRNA)-mediated interferon response and inflammation; however, a causal virus has not been identified. Here, we use a mouse model, corroborated with human islet data, to demonstrate that endogenous dsRNA in beta cells can lead to a diabetogenic immune response, thus identifying a...

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PMID: 38128529
DOI: 10.1016/j.cmet.2023.11.011

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