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Article

Comprehensive mapping of mutations in TDP-43 and α-Synuclein that affect stability and binding.

Journal of biomolecular structure & dynamics - 1 Mar 2025

Alamri Sultan H, Haque Shafiul, Alghamdi Badra S, Tayeb Haythum O, Azhari Shereen, Farsi Reem M, Elmokadem Abear, Alamri Turki A, Harakeh Steve, Prakash Amresh, Kumar Vijay

Abstract excerpt

Abnormal aggregation and amyloid inclusions of TAR DNA-binding protein 43 (TDP-43) and α-Synuclein (α-Syn) are frequently co-observed in amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease. Several reports showed TDP-43 C-terminal domain (CTD) and α-Syn interact with each other and the aggregates of these two proteins colocalized together in different cellular and animal models. Molecular...

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Identifiers

PMID: 38126188
DOI: 10.1080/07391102.2023.2293258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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