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Article

Dissecting the Effect of ALS Mutation G335D on the Early Aggregation of the TDP-43 Amyloidogenic Core Peptide: Helix-to-β-Sheet Transition and Conformational Shift.

Journal of chemical information and modeling - 12 Jun 2023

Li Fangying, Chen Yujie, Tang Yiming, Liu Xianshi, Wei Guanghong

Abstract excerpt

The aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) into fibrillary deposits is associated with amyotrophic lateral sclerosis (ALS). The 311-360 fragment of TDP-43 (TDP-43311-360), the amyloidogenic core region, can spontaneously aggregate into fibrils, and the ALS-associated mutation G335D has an enhanced effect on TDP-43311-360 fibrillization. However, the molecular mechanism underlying G335D-enhanced...

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PMID: 37218694
DOI: 10.1021/acs.jcim.3c00513

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